Dr. Sacchettini leads RTI’s drug discovery and development efforts. Presently he is Professor and Wolfe–Welch Chair in Science in the Department of Biochemistry and Biophysics at Texas A&M University. Dr. Sacchettini is also Director of the Center for Structural Biology and a faculty member at the Institute of Biosciences and Technology, Houston, Texas. Dr. Sacchettini’s research has primarily focused on studying enzyme mechanisms and the binding interactions between proteins and their ligands, substrates or inhibitors, using several techniques including X-ray crystallography, drug discovery, and molecular biology. Research in Dr. Sacchettini’s lab has led directly to the discovery forming the basis for the start-up of RTI. He holds a B.A. in Biology from St. Louis University (1980) and earned his Ph.D. in Molecular Biology from Washington University School of Medicine in St. Louis.
Dr. Fossum designs and coordinates all preclinical studies required for the validation of drug candidates. Presently she is Professor of Surgery Texas A&M University. She is a world-renowned surgeon and serves as the Director for Cardiothoracic Surgery and Biomedical Devices in the Michael E. DeBakey Institute at TAMU. She is the Director of the Texas A & M Institute for Preclinical Studies (TIPS), a $70,000,000 venture which promotes public-private partnerships to speed up the development of medical devices and drugs. She graduated from Washington State University College of Veterinary Medicine in 1982, and did a surgery residency and Master’s degree at the Ohio State University. She received board certification in Surgery (ACVS) and joined the faculty at TAMU in 1987. In 1992, she completed a PhD in Veterinary Microbiology.